abstract：CONTEXT:Barrett esophagus is a metaplastic, premalignant lesion associated with approximately 0.5% annual incidence of progression to esophageal adenocarcinoma. Diagnosis and screening of Barrett esophagus and Barrett-related dysplasia relies on histologic evaluation of endoscopic mucosal biopsies, a process that is bu...

journal_title：Archives of pathology & laboratory medicine

authors： Voltaggio L,Montgomery EA,Lam-Himlin D

更新日期：2011-10-01 00:00:00

abstract：CONTEXT:The advent of new endoscopic optical techniques is likely to change pathologists' role in diagnosis. OBJECTIVE:To describe how confocal laser endomicroscopy (CLE) works, show its advantages and limitations compared to cytohistologic biopsy, and explore how it may affect the practice of pathology. DATA SOURCES...

journal_title：Archives of pathology & laboratory medicine

authors： Paull PE,Hyatt BJ,Wassef W,Fischer AH

更新日期：2011-10-01 00:00:00

abstract：:A 67-year-old man, with multiple skin lesions that appeared over 2 years, had biopsies that disclosed granulomatous dermatitis with associated small yeasts. The urinary antigen test results were negative for Histoplasma infection; cultures from the biopsies did not grow any fungi or other potential pathogens. The ches...

journal_title：Archives of pathology & laboratory medicine

authors： Desai HB,Perkins PL,Procop GW

更新日期：2011-09-01 00:00:00

abstract：CONTEXT:Nucleophosmin 1 (NPM1) is the most commonly mutated gene in acute myeloid leukemia. Detection of NPM1 mutations is useful for stratifying patients for therapy, predicting prognosis, and assessing for minimal residual disease. Several methods have been developed to rapidly detect NPM1 mutations in genomic DNA an...

journal_title：Archives of pathology & laboratory medicine

authors： Barakat FH,Luthra R,Yin CC,Barkoh BA,Hai S,Jamil W,Bhakta YI,Chen S,Medeiros LJ,Zuo Z

更新日期：2011-08-01 00:00:00

abstract：:Myocardial abscess perforation is an extremely rare complication of infective endocarditis. We present a case of a 12-month-old infant who developed community-associated methicillin-resistant Staphylococcus aureus bacteremia after an incision and drainage of a skin abscess. He subsequently developed septic emboli to t...

journal_title：Archives of pathology & laboratory medicine

authors： Hershenson JA,Baker PB,Rowland DG

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:Recent advances in understanding the molecular basis of melanoma have resulted in development of fluorescence in situ hybridization (FISH) protocols designed to detect genetic abnormalities discriminating melanoma from nevi. The most extensively studied is a 4-probe multicolor FISH probe panel targeting chromos...

journal_title：Archives of pathology & laboratory medicine

authors： Gerami P,Zembowicz A

更新日期：2011-07-01 00:00:00

abstract：CONTEXT:Aperio Technologies, Inc (Vista, California) provides a new immunohistochemistry (IHC) HER2 Image Analysis (IA) system that allows tuning of the intensity thresholds of the HER2/ neu scoring scheme to adapt to the staining characteristics of different reagents. OBJECTIVE:To compare the trainable IHC HER2 IA sy...

journal_title：Archives of pathology & laboratory medicine

authors： Nassar A,Cohen C,Agersborg SS,Zhou W,Lynch KA,Albitar M,Barker EA,Vanderbilt BL,Thompson J,Heyman ER,Lange H,Olson A,Siddiqui MT

更新日期：2011-07-01 00:00:00

abstract：CONTEXT:Recently we have observed distinctive acidophilic intranuclear inclusions in cases of usual intraductal hyperplasia of the breast. Similar inclusions were described almost 20 years ago in cases of mammary hyperplasia. These correlated ultrastructurally with so-called helioid inclusions. However, there since has...

journal_title：Archives of pathology & laboratory medicine

authors： Lauer S,Oprea-Ilies G,Cohen C,Adsay V,Adams AL

更新日期：2011-06-01 00:00:00

abstract：CONTEXT:The development of targeted therapies in the treatment of lung carcinoma is a rapidly growing area that requires a precise histologic classification of lung carcinomas and the implementation into clinical practice of testing for predictive biomarkers of therapy response. Molecular testing has added another laye...

journal_title：Archives of pathology & laboratory medicine

authors： Dacic S

更新日期：2011-05-01 00:00:00

abstract：CONTEXT:Burkitt lymphoma (BL) is endemic in Uganda and because of the high incidence, diagnosis is often presumed during clinical care and epidemiologic studies. OBJECTIVES:To assess the accuracy of the clinical and the local pathology diagnosis of BL as assessed by an outside pathology review diagnosis and to underst...

journal_title：Archives of pathology & laboratory medicine

authors： Ogwang MD,Zhao W,Ayers LW,Mbulaiteye SM

更新日期：2011-04-01 00:00:00

abstract：:We report findings from an autopsy of a 45-year-old woman with the rare lysosomal storage disease mucolipidosis type III α/β. Her disease manifested most notably as multiple bone and cartilage problems with tracheal and bronchial malacia. Principal autopsy findings included gross abnormalities in bone and cartilage wi...

journal_title：Archives of pathology & laboratory medicine

authors： Kerr DA,Memoli VA,Cathey SS,Harris BT

更新日期：2011-04-01 00:00:00

abstract：CONTEXT:Cytologic features of low-grade neuroendocrine carcinoma are well described in primary sites. There are fewer reports of the cytologic features specific to metastatic liver lesions or the frequency of misdiagnosis. OBJECTIVE:To identify discriminating cytologic features and characterize the rate of misdiagnosi...

journal_title：Archives of pathology & laboratory medicine

authors： Clayton AC,Wasserman PG,Souers RJ,Chmara BA,Renshaw A,Wilbur DC,Moriarty AT,College of American Pathologists Cytopathology Resource Committee.

更新日期：2011-03-01 00:00:00

abstract：:Physician shortages are acute in developing countries, where disease burden is the greatest and resources for health care are very limited. A lack of pathologists in these countries has lead to delays in diagnosis and misdiagnoses that adversely affect patient care and survival. The introduction of telepathology into ...

journal_title：Archives of pathology & laboratory medicine

authors： Hitchcock CL

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Timely and accurate diagnosis of hematologic malignancies is crucial to appropriate clinical management. Acute leukemias are a diverse group of malignancies with a range of clinical presentations, prognoses, and preferred treatment protocols. Historical classification systems relied predominantly on morphologic...

journal_title：Archives of pathology & laboratory medicine

authors： Peters JM,Ansari MQ

更新日期：2011-01-01 00:00:00

abstract：CONTEXT:The rapid advances of computer technologies have created a new e-learner generation of "Homo-zappien" students that think and learn differently. Digital gaming is an effective, fun, active, and encouraging way of learning, providing immediate feedback and measurable process. Within the context of ongoing reform...

journal_title：Archives of pathology & laboratory medicine

authors： Kanthan R,Senger JL

更新日期：2011-01-01 00:00:00

abstract：:Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of me...

journal_title：Archives of pathology & laboratory medicine

authors： Kong Y,Kumar SM,Xu X

更新日期：2010-12-01 00:00:00

abstract：CONTEXT:Tumors of the head and neck commonly arise from the squamous and respiratory mucosa that lines the nasal and oral cavity, sinuses, pharynx, and larynx. The rate of oropharyngeal cancers diagnosed among Americans younger than 50 years is increasing. Infection of the oropharynx and tonsils by the human papillomav...

journal_title：Archives of pathology & laboratory medicine

authors： Black CC,Bentley HA,Davis TH,Tsongalis GJ

更新日期：2010-12-01 00:00:00

abstract：CONTEXT:Digital viewing of histologic images is moving from presentations and publications to incorporation into the daily work of practicing pathologists. Many technologic limitations have been overcome recently, which should make widespread adoption more practical. The task now is for pathologists to become actively ...

journal_title：Archives of pathology & laboratory medicine

authors： Hedvat CV

更新日期：2010-11-01 00:00:00

abstract：:Nephrogenic adenoma, also referred to as nephrogenic metaplasia, is an uncommon benign lesion of the urothelial tract, characterized by a circumscribed proliferation of tubules, cysts, and papillae lined by cells with low cuboidal to columnar epithelium. The diagnostic features that are useful in the recognition of th...

journal_title：Archives of pathology & laboratory medicine

authors： Kunju LP

更新日期：2010-10-01 00:00:00

abstract：CONTEXT:Automated cell counters use alerts (flags) to indicate which differential white blood cell counts can be released directly from the instrument and which samples require labor-intensive slide reviews. The thresholds at which many of these flags are triggered can be adjusted by individual laboratories. Many users...

journal_title：Archives of pathology & laboratory medicine

authors： Sireci A,Schlaberg R,Kratz A

更新日期：2010-10-01 00:00:00

abstract：CONTEXT:Differences in participant responses for ThinPrep (TP) and non-ThinPrep (NTP) preparations for gastrointestinal cytology challenges, which circulated in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology (CAP NGC), may help to identify performance variations betwe...

journal_title：Archives of pathology & laboratory medicine

authors： Clayton AC,Bentz JS,Wasserman PG,Schwartz MR,Souers RJ,Chmara BA,Laucirica R,Clary KM,Moriarty AT,College of American Pathologists Cytopathology Resource Committee.

更新日期：2010-08-01 00:00:00

abstract：CONTEXT:Chordoma is a rare, notochordal tumor with a characteristic histomorphology and immunohistochemical profile. At times, it presents a diagnostic challenge, especially in small biopsies. Brachyury, a nuclear transcription factor, is a recently described immunohistochemical marker for diagnosing chordomas. OBJECT...

journal_title：Archives of pathology & laboratory medicine

authors： Jambhekar NA,Rekhi B,Thorat K,Dikshit R,Agrawal M,Puri A

更新日期：2010-08-01 00:00:00

abstract：CONTEXT:'Atypical' has served as a descriptive term in cytology since the birth of the specialty by Dr Papanicolaou. This indeterminate diagnosis often results in repeat biopsies or additional tissue sampling and a needless delay in patient care if used inappropriately. Because of the definitional ambiguity of this ter...

journal_title：Archives of pathology & laboratory medicine

authors： Koen TM,Mody DR,Scheiber-Pacht M,Fairley T,Thrall MJ

更新日期：2010-07-01 00:00:00

abstract：:Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign, proliferative mesenchymal lesion with possible hormonal etiology. It typically affects women in the reproductive age group. Pseudoangiomatous stromal hyperplasia is frequently an incidental histologic finding in breast biopsies performed for other...

journal_title：Archives of pathology & laboratory medicine

authors： Virk RK,Khan A

更新日期：2010-07-01 00:00:00

abstract：CONTEXT:Although the healthy esophageal mucosa contains no eosinophils, eosinophilic infiltration is observed in 2 major clinicopathologic settings: gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EE). The prevalence of EE is increasing in many countries, and this increase seems only partly to be d...

journal_title：Archives of pathology & laboratory medicine

authors： Genevay M,Rubbia-Brandt L,Rougemont AL

更新日期：2010-06-01 00:00:00

abstract：CONTEXT:Estrogen receptor and progesterone receptor status is assessed on all newly diagnosed, invasive breast carcinomas and in recurrences to determine patient eligibility for hormonal therapy, but 10% to 20% of estrogen receptor and progesterone receptor test results are discordant when tested in multiple laboratori...

journal_title：Archives of pathology & laboratory medicine

authors： Fitzgibbons PL,Murphy DA,Hammond ME,Allred DC,Valenstein PN

更新日期：2010-06-01 00:00:00

abstract：CONTEXT:Recent discoveries have expanded the spectrum of nonneoplastic pulmonary lymphoproliferative disorders and have provided new insights into their pathogenesis and treatment. OBJECTIVE:To review the thoracic manifestations of immunoglobulin (Ig) G4-related sclerosing disease and summarize current concepts and di...

journal_title：Archives of pathology & laboratory medicine

authors： Guinee DG Jr

更新日期：2010-05-01 00:00:00

abstract：CONTEXT:Platelet-derived microparticles (PDMPs) probably function in hemostasis, thrombosis, inflammation, and transfusion-related immunomodulation. OBJECTIVE:To compare PDMP levels of leukocyte-filtered and unfiltered whole blood during storage. DESIGN:Ten whole blood donations were collected and processed. Half of ...

journal_title：Archives of pathology & laboratory medicine

authors： Sugawara A,Nollet KE,Yajima K,Saito S,Ohto H

更新日期：2010-05-01 00:00:00

abstract：CONTEXT:Glomerular cysts, defined as Bowman space dilatation greater than 2 to 3 times normal size, are found in disorders of diverse etiology and with a spectrum of clinical manifestations. The term glomerulocystic kidney (GCK) refers to a kidney with greater than 5% cystic glomeruli. Although usually a disease of the...

journal_title：Archives of pathology & laboratory medicine

authors： Lennerz JK,Spence DC,Iskandar SS,Dehner LP,Liapis H

更新日期：2010-04-01 00:00:00

abstract：CONTEXT:The differential diagnoses of prostatic carcinoma and bladder epithelial neoplasms include several histologic mimics that should be known to avoid misdiagnosis. OBJECTIVE:To discuss pseudoneoplastic lesions of the prostate and bladder that could potentially be confused with prostatic carcinoma and bladder epit...

journal_title：Archives of pathology & laboratory medicine

authors： Hameed O,Humphrey PA

更新日期：2010-03-01 00:00:00

abstract：:Intraosseous benign notochordal cell tumor is a presumably benign, intravertebral lesion of notochord origin, which can be found incidentally on removal of the vertebra for unrelated lesions or during an autopsy. The notion of a larger benign notochordal cell tumor that is macroscopic, occasionally symptomatic, and se...

journal_title：Archives of pathology & laboratory medicine

authors： Amer HZ,Hameed M

更新日期：2010-02-01 00:00:00

abstract：CONTEXT:Galectin-3, a member of the lectin family, was shown to be expressed in normal distal tubular cells and in renal cell carcinomas (RCC). However, its diagnostic and prognostic significance in RCC is as yet undefined. OBJECTIVES:To describe the expression of Galectin-3 among different histologic subtypes of rena...

journal_title：Archives of pathology & laboratory medicine

authors： Dancer JY,Truong LD,Zhai Q,Shen SS

更新日期：2010-01-01 00:00:00

abstract：CONTEXT:-Whole-slide imaging technology offers promise for rapid, Internet-based telepathology consultations between institutions. Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized. OBJECTIVE:-To determine whether interpretation of whole-slide images...

journal_title：Archives of pathology & laboratory medicine

authors： Wilbur DC,Madi K,Colvin RB,Duncan LM,Faquin WC,Ferry JA,Frosch MP,Houser SL,Kradin RL,Lauwers GY,Louis DN,Mark EJ,Mino-Kenudson M,Misdraji J,Nielsen GP,Pitman MB,Rosenberg AE,Smith RN,Sohani AR,Stone JR,Tambouret

更新日期：2009-12-01 00:00:00

abstract：CONTEXT:Malignancies of the salivary gland are uncommon and account for 0.3% of all malignancies. In addition to their rarity, diagnosing these tumors can be challenging given the histologic overlap among various subtypes, their morphologic heterogeneity, and the recent recognition of new entities. OBJECTIVE:To provid...

journal_title：Archives of pathology & laboratory medicine

authors： McHugh JB,Visscher DW,Barnes EL

更新日期：2009-11-01 00:00:00

abstract：CONTEXT:Primary intraosseous squamous cell carcinoma is a rare form of squamous cell carcinoma, arising within the jaws. OBJECTIVE:To clarify the clinicopathologic and behavioral spectrum of primary intraosseous squamous cell carcinoma. DESIGN:The clinical and pathologic findings, treatment, and follow-up data of 39 ...

journal_title：Archives of pathology & laboratory medicine

authors： Huang JW,Luo HY,Li Q,Li TJ

更新日期：2009-11-01 00:00:00

abstract：CONTEXT:KRAS mutations can be detected in approximately 30% to 40% of all patients with colorectal cancer. Several recent studies have shown that patients with KRAS mutations in codons 12 or 13 in metastatic tumors do not benefit from anti-epidermal growth factor receptor therapy with cetuximab or panitumumab. OBJECTI...

journal_title：Archives of pathology & laboratory medicine

authors： Monzon FA,Ogino S,Hammond ME,Halling KC,Bloom KJ,Nikiforova MN

更新日期：2009-10-01 00:00:00

abstract：CONTEXT:Recent changes in pathology residency education have included a decrease in the program length (from 5 years to 4 years for combined anatomic and clinical pathology training) and a national mandate for programs to assess 6 general competencies of trainees. These have undoubtedly led to changes in program curric...

journal_title：Archives of pathology & laboratory medicine

authors： Lagwinski N,Hunt JL

更新日期：2009-09-01 00:00:00

abstract：:Mixed epithelial and stromal tumor of the kidney is a recently recognized distinct neoplasm that should be distinguished from other renal neoplasms. These tumors are relatively rare with a female preponderance. Imaging studies are not diagnostic but reveal a solid or solid and cystic mass in most cases. Histopathologi...

journal_title：Archives of pathology & laboratory medicine

authors： Mohanty SK,Parwani AV

更新日期：2009-09-01 00:00:00

abstract：CONTEXT:Certain histopathologic risk factors in enucleated eyes are important indicators for adjuvant chemotherapy in patients with retinoblastoma. OBJECTIVES:To determine the frequency of histopathologic risk factors in a large series of retinoblastomas treated by enucleation on file in the pathology laboratory of a ...

journal_title：Archives of pathology & laboratory medicine

authors： Eagle RC Jr

更新日期：2009-08-01 00:00:00

abstract：:Progressive sclerosing orbital pseudotumors are a subset of usually primary and localized idiopathic fibroinflammatory disorders. We report on a 66-year-old man who developed this condition along the facial tissue planes with extension into the orbit and preferential involvement of the periorbital membrane. Fibrocolla...

journal_title：Archives of pathology & laboratory medicine

authors： Mehta M,Jakobiec F,Fay A

更新日期：2009-08-01 00:00:00